The CarbonSAFE Central Appalachian Basin project (Department of Energy Award Number DE-FE0029466) provided an integrated prefeasibility study of the Central Appalachian Basin. The project focused on Eastern Ohio, where storage potential has been previously defined in Cambrian-Ordovician age carbonate and sandstone formations. Phase I began the process of taking into account all the technical, socio-economic, scientific, and legislative aspects related to implementation of a carbon capture and storage (CCS) project in this area. Source suitability was assessed by identifying electricity generation and/or industrial sources large enough to provide CO2 emissions for a commercial-scale storage project. Because of its importance to Ohio’s economy, sources that use coal were a focus of this assessment. Geological suitability was assessed through the identification of geologic areas that can safely and permanently store CO2 for a commercial-scale CCS project (i.e., 50 million metric tonnes over 30 years). This assessment found sufficient CO2 storage capacity, high injectivity within the storage zone, presence of a thick and competent geologic seal (caprock), and low risk for tectonic activity and CO2 leakage. Project definition and integration factors including project dimensions, infrastructure requirements, mineral and property rights, economics, regulatory/political/technology issues, permitting, public outreach, and project liability were evaluated.